The drug is the furthest along of T Cell's experimental drugs known as complement inhibitors.
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In addition, to delay the disease the complement inhibitor needs to be used before symptoms develop.
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Given the role of the complement system in GBS, it has been suggested that complement inhibitors ( such as the drug eculizumab ) may be effective.
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A number of drugs are being studied : aquaporumab ( non-pathogenic antibody blocker of AQP4-IgG binding ), sivelestat ( neutrophil elastase inhibitor ), and eculizumab ( complement inhibitor ).
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In recent years the monoclonal antibody eculizumab ( complement inhibitor, has been shown in clinical studies to block terminal complement activity in children and adults with aHUS, and to eliminate the need for PE / PI and new dialysis.
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The genes coding for C4BP ?-chain ( C4BPA ) and ?-chain ( C4BPB ) are located in the regulators of complement activation ( RCA ) gene cluster on the long arm of chromosome 1 in the vicinity of other complement inhibitors.
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His laboratory contributed in the development of complement-based anti-inflammatory therapeutics through the discovery of the first small-size complement inhibitor, termed Compstatin, which has exhibited consistent efficacy for use in a series of in vivo trials and shows great promise for the use in the clinic.
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"While we are not advocating that people or animals should be treated with cobra venom factor, our findings suggest that complement inhibitors may present an opportunity for early therapeutic intervention in these diseases, in the interval between exposure to infection " and invasion of the brain, Mabbott said.
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Over 1280 protein families have been associated with the saliva of blood feeding organisms, including inhibitors of platelet aggregation, ADP, arachidonic acid, thrombin, PAF, anticoagulants, vasodilators, vasoconstrictors, antihistamines, sodium channel blockers, complement inhibitors, pore formers, inhibitors of angiogenesis, anaesthetics, AMPs and microbial pattern recognition molecules, and parasite enhancers / activators.
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